Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms.

@article{Timmer2004EnhancedSR,
  title={Enhanced survival, reinnervation, and functional recovery of intrastriatal dopamine grafts co-transplanted with Schwann cells overexpressing high molecular weight FGF-2 isoforms.},
  author={Marco Timmer and Frauke M{\"u}ller-Ostermeyer and Verena Kloth and Christian Winkler and Claudia B. Grothe and Guido Nikkhah},
  journal={Experimental neurology},
  year={2004},
  volume={187 1},
  pages={118-36}
}
Dopaminergic (DA) micrografts were co-transplanted with Schwann cells (SC) overexpressing 18 kDa and 21/23 kDa FGF-2 into the caudate-putamen unit (CPu) of unilaterally 6-hydroxydopamine-lesioned rats. We report here that SC engineered to overexpress FGF-2 promoted DA-graft-induced restoration, whether co-transplanted at the same site or grafted at a second more distant site within the CPu. In addition, the 21/23 kDa FGF-2 isoforms resulted in a significantly better reinnervation and survival… CONTINUE READING
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