Enhanced suicide gene effect by adenoviral transduction of a VP22-cytosine deaminase (CD) fusion gene

@article{Wybranietz2001EnhancedSG,
  title={Enhanced suicide gene effect by adenoviral transduction of a VP22-cytosine deaminase (CD) fusion gene},
  author={WA Wybranietz and C T Gross and Anne Phelan and Peter O'Hare and Martin Spiegel and Florian T C Graepler and Michael Bitzer and Peer Friedrich St{\"a}hler and Michael Gregor and U Lauer},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={1654-1664}
}
The low transduction efficiency of viral and nonviral vectors is a major limitation in tumour gene therapy. The HSV-1 tegument protein VP22 has been shown to exhibit a novel intercellular transport property. VP22 wild-type as well as VP22 fusion proteins efficiently spread from the original expressing cell to numerous neighbouring cells, so that protein transport by VP22 chimaeric polypeptides into the surrounding cells offers a possible compensation for the inadequate gene transfer… CONTINUE READING

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