Enhanced stereotyped response to amphetamine after pretreatment with small doses of molindone

@article{Conway1983EnhancedSR,
  title={Enhanced stereotyped response to amphetamine after pretreatment with small doses of molindone},
  author={Paul G. Conway and Norman J. Uretsky},
  journal={Neuropharmacology},
  year={1983},
  volume={22},
  pages={579-586}
}
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5 Citations
Background Citations
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5 Citations

Effects of buspirone on dopamine dependent behaviours in rats.
TLDR
Results indicate that buspirone by selectively blocking presynaptic nigrostriatal D2 DA autoreceptors, increases synthesis of DA and makes more DA available for release by dexamphetamine and during haloperidol-induced compensatory 'feedback' increase of nigrostRIatal DAergic neuronal activity and thus potentiates dexamphetamine stereotypy and antagonizes haloperIDol catalepsy.
Effects of the antidepressant trazodone, a 5-HT2A/2C receptor antagonist, on dopamine-dependent behaviors in rats
TLDR
It is suggested that trazodone (5, 10 and 20 mg/kg), by blocking the 5-HT2C receptors, releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5- HT, and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy.
3-Methoxytyramine accumulation: Effects of typical neuroleptics and various atypical compounds
TLDR
The observation that SCH 23390, a D- 1 DA receptor antagonist, had negligible effects on 3-MT accumulation suggests that D-1 receptor blockade, unlike D-2 blockade, may have minimal effects on DA release.
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia
Molindone: higher doses needed to block pergolide-induced elevation of serum corticosterone than to elevate dopamine metabolites in brain.

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