Enhanced stereotyped response to amphetamine after pretreatment with small doses of molindone

  title={Enhanced stereotyped response to amphetamine after pretreatment with small doses of molindone},
  author={Paul G. Conway and Norman J. Uretsky},
Pretreatment of rats with small doses of the antipsychotic drug, molindone, enhanced the stereotyped behavioral response to amphetamine. In order to determine whether molindone enhanced amphetamine-induced stereotypy by the same mechanism as chronic administration of amphetamine or drugs that inhibit central noradrenergic transmission, the effect of these drugs on the stereotyped behavior produced by beta-phenethylamine (PEA) was compared. Following the administration of phenoxybenzamine… Expand
Effects of buspirone on dopamine dependent behaviours in rats.
Results indicate that buspirone by selectively blocking presynaptic nigrostriatal D2 DA autoreceptors, increases synthesis of DA and makes more DA available for release by dexamphetamine and during haloperidol-induced compensatory 'feedback' increase of nigrostRIatal DAergic neuronal activity and thus potentiates dexamphetamine stereotypy and antagonizes haloperIDol catalepsy. Expand
Effects of the antidepressant trazodone, a 5-HT2A/2C receptor antagonist, on dopamine-dependent behaviors in rats
It is suggested that trazodone (5, 10 and 20 mg/kg), by blocking the 5-HT2C receptors, releases the nigrostriatal DAergic neurons from tonic inhibition caused by 5- HT, and thereby potentiates dexamphetamine stereotypy and antagonizes haloperidol catalepsy. Expand
Molindone compared to haloperidol in a guinea-pig model of tardive dyskinesia
Molindone potentiated dopaminergic activity in animal models in a similar way to other neuroleptics, suggesting that its use may also result in tardive dyskinesia. Expand
3-Methoxytyramine accumulation: Effects of typical neuroleptics and various atypical compounds
The observation that SCH 23390, a D- 1 DA receptor antagonist, had negligible effects on 3-MT accumulation suggests that D-1 receptor blockade, unlike D-2 blockade, may have minimal effects on DA release. Expand
Molindone: higher doses needed to block pergolide-induced elevation of serum corticosterone than to elevate dopamine metabolites in brain.
Molindone at a dose of 3 mg/kg i.p. in rats prevented pergolide-induced decreases in brain DOPAC and HVA, causing instead significant increases in these dopamine metabolites when given in combination with pergOLide. Expand


Chronic amphetamine: Is dopamine a link in or a mediator of the development of tolerance and reverse tolerance?
While DA systems appear to be a critical link, not only in the acute effects of AMPH, but also in the development of tolerance and reverse tolerance, most of the behavioral differences between acutely and chronically treated animals are not reflected by comparable differences in DA synthesis and metabolism. Expand
Noradrenergic influence on the stereotyped behaviour induced by amphetamine, phenethylamine and apomorphine
The ability of drugs with effects on central noradrenaline mechanisms to change the amphetamine or apomorphine-induced stereotyped sniffing into gnawing or biting is investigated and it is suggested that the qualitative expression of stereotyped behaviour in different behavioural elements, here more specifically as a transition between sniffing, Gnawing and licking, is also influenced by central nor adrenaline transmission. Expand
Antiamphetamine effects following inhibition of tyrosine hydroxylase.
The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects. Expand
The different actions of amphetamine and reserpine on the metabolism of H3-norepinephrine indicate the presence of more than one storage form of the brain catecholamine. Expand
Amphetamine-induced dopaminergic hypersensitivity in guinea pigs. Implications in psychosis and human movement disorders.
Following chronic amphetamine pretreatment, guinea pigs demonstrate an increased sensitivity to both d-amphetamine sulfate- and apomorphine hydrochloride-induced stereotyped behavior. ThisExpand
Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.
  • U. Ungerstedt
  • Chemistry, Medicine
  • Acta physiologica Scandinavica. Supplementum
  • 1971
Amphetamine induced vigorous rotational behaviour in rats where the nigrostriatal dopamine system was unilaterally degenerated by an intracerebral injection of 6-hydroxydopamine (6-OH-DA) and evidence was obtained that the amphetamine induced release of DA was dependent upon nerve impulses. Expand
Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brain
The relative affinities of neuroleptics for WB-4101 binding sites and for dopamine receptors as labeled by [3H]haloperidol provides an index of the relative propensities of these drugs for eliciting autonomic side effects such as orthostatic hypotension and sedation. Expand
D-amphetamine-induced release of "newly synthesized" and "stored" dopamine from the caudate nucleus in vivo.
  • C. Chiueh, K. Moore
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1975
The results suggest that damphetamine can release both "stored" and "newly synthesized" 3H-dopamine from the caudate nucleus, but that the maintenance of the amphetamine-induced release of dopamine is dependent upon the newly synthetized pool. Expand
Behavioral effects of dopamine and p-hydroxyamphetamine injected into corpus striatum of rats.
It is strongly indicated that the amphetamine-type of stereotyped behavior is mediated through dopaminergic mechanisms in the corpus striatum. Expand
Mode of action of psychomotor stimulant drugs.
Publisher Summary Amphetamine or “Weckaminen” and a number of related drugs are classified as “psychomotor stimulant drugs.” Alertness, suppression of fatigue and sleepiness, stimulation of motorExpand