Enhanced stereotyped response to amphetamine after pretreatment with small doses of molindone

@article{Conway1983EnhancedSR,
  title={Enhanced stereotyped response to amphetamine after pretreatment with small doses of molindone},
  author={Paul G. Conway and Norman J. Uretsky},
  journal={Neuropharmacology},
  year={1983},
  volume={22},
  pages={579-586}
}
Pretreatment of rats with small doses of the antipsychotic drug, molindone, enhanced the stereotyped behavioral response to amphetamine. In order to determine whether molindone enhanced amphetamine-induced stereotypy by the same mechanism as chronic administration of amphetamine or drugs that inhibit central noradrenergic transmission, the effect of these drugs on the stereotyped behavior produced by beta-phenethylamine (PEA) was compared. Following the administration of phenoxybenzamine… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Chronic amphetamine: Is dopamine a link in or a mediator of the development of tolerance and reverse tolerance?
TLDR
While DA systems appear to be a critical link, not only in the acute effects of AMPH, but also in the development of tolerance and reverse tolerance, most of the behavioral differences between acutely and chronically treated animals are not reflected by comparable differences in DA synthesis and metabolism. Expand
Noradrenergic influence on the stereotyped behaviour induced by amphetamine, phenethylamine and apomorphine
TLDR
The ability of drugs with effects on central noradrenaline mechanisms to change the amphetamine or apomorphine-induced stereotyped sniffing into gnawing or biting is investigated and it is suggested that the qualitative expression of stereotyped behaviour in different behavioural elements, here more specifically as a transition between sniffing, Gnawing and licking, is also influenced by central nor adrenaline transmission. Expand
Antiamphetamine effects following inhibition of tyrosine hydroxylase.
TLDR
The antiamphetamine effects of α-MT and other tyrosine hydroxylase inhibitors suggest that a critical level of norepinephrine at the receptor is required for amphetamine to exert its customary effects. Expand
EFFECT OF DRUGS ON THE UPTAKE, RELEASE, AND METABOLISM OF H3-NOREPINEPHRINE IN THE RAT BRAIN.
TLDR
The different actions of amphetamine and reserpine on the metabolism of H3-norepinephrine indicate the presence of more than one storage form of the brain catecholamine. Expand
Amphetamine-induced dopaminergic hypersensitivity in guinea pigs. Implications in psychosis and human movement disorders.
Following chronic amphetamine pretreatment, guinea pigs demonstrate an increased sensitivity to both d-amphetamine sulfate- and apomorphine hydrochloride-induced stereotyped behavior. This… Expand
Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour.
  • U. Ungerstedt
  • Chemistry, Medicine
  • Acta physiologica Scandinavica. Supplementum
  • 1971
TLDR
Amphetamine induced vigorous rotational behaviour in rats where the nigrostriatal dopamine system was unilaterally degenerated by an intracerebral injection of 6-hydroxydopamine (6-OH-DA) and evidence was obtained that the amphetamine induced release of DA was dependent upon nerve impulses. Expand
Neuroleptic drug interactions with norepinephrine alpha receptor binding sites in rat brain
TLDR
The relative affinities of neuroleptics for WB-4101 binding sites and for dopamine receptors as labeled by [3H]haloperidol provides an index of the relative propensities of these drugs for eliciting autonomic side effects such as orthostatic hypotension and sedation. Expand
D-amphetamine-induced release of "newly synthesized" and "stored" dopamine from the caudate nucleus in vivo.
  • C. Chiueh, K. Moore
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
  • 1975
TLDR
The results suggest that damphetamine can release both "stored" and "newly synthesized" 3H-dopamine from the caudate nucleus, but that the maintenance of the amphetamine-induced release of dopamine is dependent upon the newly synthetized pool. Expand
Behavioral effects of dopamine and p-hydroxyamphetamine injected into corpus striatum of rats.
TLDR
It is strongly indicated that the amphetamine-type of stereotyped behavior is mediated through dopaminergic mechanisms in the corpus striatum. Expand
Mode of action of psychomotor stimulant drugs.
Publisher Summary Amphetamine or “Weckaminen” and a number of related drugs are classified as “psychomotor stimulant drugs.” Alertness, suppression of fatigue and sleepiness, stimulation of motor… Expand
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