Enhanced stem cell engraftment and modulation of hepatic reactive oxygen species production in diet-induced obesity.

@article{Nyamandi2014EnhancedSC,
  title={Enhanced stem cell engraftment and modulation of hepatic reactive oxygen species production in diet-induced obesity.},
  author={Vongai Z Nyamandi and Virginia L. Johnsen and Curtis C. Hughey and Dustin S. Hittel and Aneal A Khan and Christopher Newell and Jane Shearer},
  journal={Obesity},
  year={2014},
  volume={22 3},
  pages={721-9}
}
OBJECTIVE The impact of dietary-induced obesity (DIO) on stem cell engraftment and the respective therapeutic potential of stem cell engraftment in DIO have not been reported. The objectives of this study were to examine the impact of DIO on the survival and efficacy of intravenous bone marrow-derived mesenchymal stem cell (MSC) administration in the conscious C57BL/6 mouse. METHODS Male mice consumed either a chow (CH) or high fat (HF, 60% kcal) diet for 18 weeks and were subsequently… CONTINUE READING