Enhanced spontaneous transmitter release at murine motor nerve terminals with cyclosporine.

@article{Lin1999EnhancedST,
  title={Enhanced spontaneous transmitter release at murine motor nerve terminals with cyclosporine.},
  author={M J Lin and S Y Lin-shiau},
  journal={Neuropharmacology},
  year={1999},
  volume={38 1},
  pages={195-8}
}
Cyclosporine, a calcineurin inhibitor, significantly enhances spontaneous acetylcholine release after a brief tetanus and potentiates the effect of phorbol 12,13-dibutyrate. Both actions are prevented by the protein kinase C inhibitor, bisindolylmaleimide iodide. Protein kinase C and calcineurin thus play important roles in the balance between phosphorylation and dephosphorylation regulating spontaneous transmitter release at motor nerve terminals. 

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