Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.

Abstract

Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among plasma-protective proteins against oxidative damage caused by red blood cell rupture, haptoglobin and hemopexin are thought to play a crucial role. Haptoglobin and hemopexin, by binding with high-affinity… (More)

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@article{Tolosano2002EnhancedSA, title={Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.}, author={Emanuela Tolosano and Sharmila Fagoonee and Emilio Hirsch and Franklin G. Berger and Heinz Baumann and Lorenzo Silengo and Fiorella Altruda}, journal={Blood}, year={2002}, volume={100 12}, pages={4201-8} }