Enhanced specificity of truncated transmembrane protein for serologic confirmation of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 infections by western blot (immunoblot) assay containing recombinant envelope glycoproteins.

@article{Varma1995EnhancedSO,
  title={Enhanced specificity of truncated transmembrane protein for serologic confirmation of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2 infections by western blot (immunoblot) assay containing recombinant envelope glycoproteins.},
  author={Manju Varma and Donna L. Rudolph and Marlyse C Knuchel and William M Switzer and Kenneth G. Hadlock and Mark D. Velligan and L. M. Chan and Steven K. H. Foung and Renu B. Lal},
  journal={Journal of clinical microbiology},
  year={1995},
  volume={33 12},
  pages={3239-44}
}
Immunoassays based on the highly immunogenic transmembrane protein of human T-cell lymphotropic virus type 1 (HTLV-1) (protein 21c) are capable of detecting antibodies in all individuals infected with HTLV-1 and HTLV-2. However, because of antigenic mimicry with other cellular and viral proteins, such assays also have a large proportion of false-positive reactions. We have recently identified an immunodominant epitope, designated GD21-I located within amino acids 361 to 404 of the transmembrane… CONTINUE READING