Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice.

@article{Barrett2010EnhancedSM,
  title={Enhanced spatial memory and hippocampal long-term potentiation in p75 neurotrophin receptor knockout mice.},
  author={Graham L. Barrett and Christopher A. Reid and Christina Tsafoulis and Wenmei Zhu and David A Williams and Antonio Paolini and Jennifer Trieu and Mark Murphy},
  journal={Hippocampus},
  year={2010},
  volume={20 1},
  pages={145-52}
}
Previous reports have described increases in the size and number of cholinergic neurons in the basal forebrain in p75 neurotrophin receptor (p75(NTR)) knockout mice. In an earlier study, we also found improved spatial memory in these mice, raising the possibility that p75(NTR) regulates hippocampal function by its effects on the cholinergic basal forebrain. We therefore investigated hippocampal long-term potentiation in p75(NTR) knockout mice that shared the same genetic background as control… CONTINUE READING