Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles.

@article{Tran2013EnhancedSA,
  title={Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles.},
  author={Phuong Ha-Lien Tran and Thao Truong-Dinh Tran and Beom-Jin Lee},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={455 1-2},
  pages={
          235-40
        }
}
Recently, we synthesized novel amphiphilic gelatin-oleic acid (GO) conjugate to prepare self-assembled nanoparticles for drug delivery. The aim of this study was to investigate pharmaceutical potentialities of self-assembled GO nanoparticles for solubility enhancement and modified release of poorly water-soluble drugs. Three poorly water-soluble model drugs with different pH-dependent solubility (valsartan and aceclofenac, insoluble at pH 1.2; telmisartan, insoluble at pH 6.8) were chosen to… CONTINUE READING

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