Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation.

@article{Yamamoto2002EnhancedSC,
  title={Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation.},
  author={Hanako Yamamoto and Takahiro Ochiya and Fumitaka Takeshita and Hiroyasu Toriyama-Baba and Kotaro Hirai and Hideo Sasaki and Hiroki Sasaki and Hiromi Sakamoto and Teruhiko Yoshida and Izumu Saito and Masaaki Terada},
  journal={Cancer research},
  year={2002},
  volume={62 6},
  pages={1641-7}
}
Cyclin D1 is a critical gene involved in the regulation of progression through the G(1) phase of the cell cycle, thereby contributing to cell proliferation. Gene amplification and abnormal expression of Cyclin D1 have been described in several human cancers. To understand their biological significance in skin carcinogenesis, we established Cyclin D1-conditional transgenic mice with C57BL/6J background, in which skin-specific overexpression of Cyclin D1 transgene was observed. The mice were… CONTINUE READING
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