Enhanced sinusoidal glutathione efflux during endotoxin-induced oxidant stress in vivo.

@article{Jaeschke1992EnhancedSG,
  title={Enhanced sinusoidal glutathione efflux during endotoxin-induced oxidant stress in vivo.},
  author={Hartmut Jaeschke},
  journal={The American journal of physiology},
  year={1992},
  volume={263 1 Pt 1},
  pages={G60-8}
}
Hepatic release of reduced glutathione (GSH) and its oxidation [glutathione disulfide (GSSG) formation] were investigated in male Fischer rats in vivo after administration of various doses (1-15 mg/kg) of endotoxin (Salmonella enteritidis). Endotoxin dose dependently enhanced basal plasma glutathione (9.64 +/- 0.80 microM) and GSSG (1.08 +/- 0.23 microM GSH equivalents) levels by up to 450 and 1,300%, respectively, 60 min after administration of the highest dose. Determination of arteriovenous… CONTINUE READING
22 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

Similar Papers

Loading similar papers…