Enhanced sensitivity to acute angiotensin II is testosterone dependent in adult male growth-restricted offspring.

@article{Ojeda2010EnhancedST,
  title={Enhanced sensitivity to acute angiotensin II is testosterone dependent in adult male growth-restricted offspring.},
  author={Norma Beatriz Ojeda and Thomas P Royals and Joshua T Black and John Henry Dasinger and Jeremy M. Johnson and Barbara T. Alexander},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010},
  volume={298 5},
  pages={R1421-7}
}
Placental insufficiency results in intrauterine growth restriction (IUGR) and hypertension in adult male growth-restricted rats. Although renal ANG II and plasma renin activity do not differ between growth-restricted and control rats, blockade of the renin-angiotensin system (RAS) abolishes hypertension in growth-restricted rats, suggesting that the RAS contributes to IUGR-induced hypertension. Moreover, castration abolishes hypertension in growth-restricted rats, indicating an important role… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Testosterone and blood pressure regulation.

Kidney & blood pressure research • 2008
View 1 Excerpt

Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring.

American journal of physiology. Regulatory, integrative and comparative physiology • 2007
View 7 Excerpts

The origins of the developmental origins theory

DJ Barker
J Intern Med • 2007
View 1 Excerpt

Androgens augment renal vascular responses to ANG II in New Zealand genetically hypertensive rats.

American journal of physiology. Regulatory, integrative and comparative physiology • 2006
View 2 Excerpts

Similar Papers

Loading similar papers…