Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism.

@article{Gianoulakis1996EnhancedSO,
  title={Enhanced sensitivity of pituitary beta-endorphin to ethanol in subjects at high risk of alcoholism.},
  author={Christina Gianoulakis and Binu Krishnan and Joseph X. Thavundayil},
  journal={Archives of general psychiatry},
  year={1996},
  volume={53 3},
  pages={250-7}
}
BACKGROUND Previous studies have demonstrated that a moderate dose of ethanol induced a significant increase in the plasma beta-endorphin content of subjects from families with a history of alcoholism (high risk (HR)), but not subjects from families without a history of alcoholism (low risk (LR)). The objective of this study was to examine the response of the pituitary beta-endorphin and adrenal cortisol systems to various concentrations of ethanol in male and female subjects at high and low… CONTINUE READING
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