Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA.

@article{Dayanc2013EnhancedSO,
  title={Enhanced sensitivity of colon tumour cells to natural killer cell cytotoxicity after mild thermal stress is regulated through HSF1-mediated expression of MICA.},
  author={Baris E Dayanc and Sanjay Bansal and Ali Osmay Gure and Sandra O Gollnick and Elizabeth A. Repasky},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={2013},
  volume={29 5},
  pages={480-90}
}
PURPOSE Previously we showed that mild thermal stress increased natural killer (NK) cell-mediated tumour cytotoxicity and that this could be blocked by anti-NKG2D or anti-MICA (major histolocompatability complex (MHC) class I related chain A) antibodies. Here, we investigated the role of the transcription factor heat shock factor 1 (HSF1) in thermal regulation of MICA expression in tumour cells in vitro and in vivo. MATERIALS AND METHODS Hyperthermia experiments were conducted in vitro and in… CONTINUE READING
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