Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract.

Abstract

Nuclear factor-E2-related factor 2 (Nrf2) is an important cytoprotective transcription factor because Nrf2-regulated enzymes play a key role in antioxidant and detoxification processes. Recent studies have reported that lung cancer cells overexpressing Nrf2 exhibit increased resistance to chemotherapy. Suppression of overexpressed Nrf2 is needed for a new… (More)
DOI: 10.1016/j.bbrc.2011.09.014

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Cite this paper

@article{Ohnuma2011EnhancedSO, title={Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract.}, author={Tomokazu Ohnuma and Takashi Matsumoto and Ayano Itoi and Ayako Kawana and Takahito Nishiyama and Kenichiro Ogura and Akira Hiratsuka}, journal={Biochemical and biophysical research communications}, year={2011}, volume={413 4}, pages={623-9} }