Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase.

@article{Hey2006EnhancedSP,
  title={Enhanced seed phytosterol accumulation through expression of a modified HMG-CoA reductase.},
  author={Sandra J. Hey and Stephen J. Powers and Michael H. Beale and Nathaniel D. Hawkins and Jane L. Ward and Nigel G Halford},
  journal={Plant biotechnology journal},
  year={2006},
  volume={4 2},
  pages={219-29}
}
The regulation of phytosterol biosynthesis in seeds is of interest to biotechnologists because of the efficacy of dietary phytosterols in reducing blood cholesterol in humans. Mevalonate synthesis via 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) is a key step in phytosterol biosynthesis. HMG-CoA reductase is inactivated by phosphorylation by SNF1-related protein kinase 1 (SnRK1). With the aim of increasing seed phytosterol levels, transgenic tobacco plants were produced… CONTINUE READING

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