Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences.

@article{Sugio2011EnhancedSP,
  title={Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences.},
  author={Kumiko Sugio and Fuminori Sakurai and Kazufumi Katayama and Katsuhisa Tashiro and Hayato Matsui and Kenji Kawabata and Atsushi Kawase and Masahiro Iwaki and Takao Hayakawa and Toshiyoshi Fujiwara and Hiroyuki Mizuguchi},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 9},
  pages={2807-18}
}
PURPOSE Oncolytic adenoviruses (Ad) have been actively pursued as potential agents for cancer treatment. Among the various types of oncolytic Ads, the telomerase-specific replication-competent Ad (TRAD), which possesses an E1 gene expression cassette driven by the human telomerase reverse transcriptase promoter, has shown promising results in human clinical trials; however, the E1 gene is also slightly expressed in normal cells, leading to replication of TRAD and cellular toxicity in normal… CONTINUE READING
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