Enhanced retention and cellular uptake of nanoparticles in tumors by controlling their aggregation behavior.

@article{Liu2013EnhancedRA,
  title={Enhanced retention and cellular uptake of nanoparticles in tumors by controlling their aggregation behavior.},
  author={X. Liu and Yangjun Chen and Huan Li and Nan Huang and Qiao Jin and K. Ren and J. Ji},
  journal={ACS nano},
  year={2013},
  volume={7 7},
  pages={
          6244-57
        }
}
Effective accumulation of nanoparticles (NPs) in tumors is crucial for NP-assisted cancer diagnosis and treatment. With the hypothesis that aggregation of NPs stimulated by tumor microenvironment can be utilized to enhance retention and cellular uptake of NPs in tumors, we designed a smart NP system to evaluate the effect of aggregation on NPs' accumulation in tumor tissue. Gold nanoparticles (AuNPs, ~16 nm) were facilely prepared by surface modification with mixed-charge zwitterionic self… Expand
Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications
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