Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis.

@article{Hasegawa1994EnhancedRO,
  title={Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis.},
  author={Kiyoshi Hasegawa and J Huang and Sharon A. Rogers and H. E. Blum and Tehming Liang},
  journal={Journal of virology},
  year={1994},
  volume={68 3},
  pages={1651-9}
}
Hepatitis B virus (HBV) mutants unable to synthesize HBV e antigen have been described in association with fulminant hepatitis. We have cloned and sequenced the entire viral genome of an HBV strain associated with an epidemic of fulminant hepatitis. This strain contained, in addition to two G-to-A mutations in the precore region (nucleotides 1898 and 1901), numerous other mutations in conserved nucleotide positions resulting in significant amino acid substitutions in HBV gene products. We… CONTINUE READING

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