Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy

@article{Wynne2007EnhancedRO,
  title={Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy},
  author={Patricia Wynne and C. O. Newton and Jonathan A Ledermann and Adeola Olaitan and Tim A Mould and John A. Hartley},
  journal={British Journal of Cancer},
  year={2007},
  volume={97},
  pages={927 - 933}
}
Despite high tumour response rates to platinum-based chemotherapy in ovarian cancer survival is poor due to the emergence of drug resistance. Mechanistic studies in clinical material have been hampered by the unavailability of sensitive methods to detect the critical drug-induced effects in individual cells. A modification of the single cell gel electrophoresis (comet) assay allows the sensitive detection of DNA interstrand crosslinking in both tumour and normal cells derived directly from… CONTINUE READING

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