Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats.

@article{Jacinto1999EnhancedRV,
  title={Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats.},
  author={Severina M. Jacinto and John J. Mullins and Kenneth D. Mitchell},
  journal={The American journal of physiology},
  year={1999},
  volume={276 2 Pt 2},
  pages={F315-22}
}
The present study was performed to evaluate renal vascular responsiveness (RVR) to ANG II in hypertensive transgenic rats [TGR; strain TGR(mRen2)27] harboring the mouse ren-2 renin gene. Renal blood flow (RBF) responses to either intravenous or intrarenal arterial administration of ANG II were assessed in pentobarbital sodium-anesthetized female heterozygous TGR (9-12 wk old) and age-matched transgene-negative Hanover Sprague-Dawley rats (HanSD). Intravenous bolus injections of 15 and 30 ng ANG… CONTINUE READING

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