Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism.

@article{Weidenbach2000EnhancedRO,
  title={Enhanced reduction of myocardial infarct size by combined ACE inhibition and AT(1)-receptor antagonism.},
  author={R. Weidenbach and Rainer Schulz and Petra Gres and Matthias Behrends and Heiner Post and Gerd Heusch},
  journal={British journal of pharmacology},
  year={2000},
  volume={131 1},
  pages={138-44}
}
The effects of the angiotensin-converting-enzyme inhibitor (ACEI) ramiprilat, the angiotensin II type 1 receptor antagonist (AT(1)A) candesartan, and the combination of both drugs on infarct size (IS) resulting from regional myocardial ischaemia were studied in pigs. Both ACEI and AT(1)A reduce myocardial IS by a bradykinin-mediated process. It is unclear, however, whether the combination of ACEI and AT(1)A produces a more pronounced IS reduction than each of these drugs alone. Forty-six… CONTINUE READING