Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein

@article{Carpentier2012EnhancedPE,
  title={Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein},
  author={David C J Carpentier and Kristis Vevis and Antonio Trabalza and Christos Georgiadis and Stuart M Ellison and Rowan I Asfahani and Nicholas D Mazarakis},
  journal={Gene Therapy},
  year={2012},
  volume={19},
  pages={761-774}
}
Rabies virus glycoprotein (RVG) can pseudotype lentiviral vectors, although at a lower efficiency to that of vesicular stomatitis virus glycoprotein (VSVG). Transduction with VSVG-pseudotyped vectors of rodent central nervous system (CNS) leads to local neurotropic gene transfer, whereas with RVG-pseudotyped vectors additional disperse transduction of… CONTINUE READING