Enhanced protection from renal ischemia-reperfusion [correction of ischemia:reperfusion] injury with A(2A)-adenosine receptor activation and PDE 4 inhibition.

@article{Okusa2001EnhancedPF,
  title={Enhanced protection from renal ischemia-reperfusion [correction of ischemia:reperfusion] injury with A(2A)-adenosine receptor activation and PDE 4 inhibition.},
  author={Mark Douglas Okusa and Joel M Linden and Liping Huang and Diane. L. Rosin and Donald F. Smith and Gareth Sullivan},
  journal={Kidney international},
  year={2001},
  volume={59 6},
  pages={2114-25}
}
BACKGROUND We previously demonstrated in rats and mice that agonists of A(2A)-adenosine receptors (A(2A)-ARs) reduce renal injury following ischemia-reperfusion. We now extend these studies and examine the effects of ATL-146e (formerly DWH-146e), an A(2A)-AR agonist, and rolipram, a type IV phosphodiesterase (PDE 4) inhibitor, on murine renal injury following ischemia-reperfusion. METHODS C57BL/6 mice were treated with rolipram, ATL-146e, or both compounds combined and were subjected to renal… CONTINUE READING