Enhanced proteasome-dependent degradation of the CDK inhibitor p27(kip1) in immortalized lymphocytes from Alzheimer's dementia patients.

@article{Muoz2008EnhancedPD,
  title={Enhanced proteasome-dependent degradation of the CDK inhibitor p27(kip1) in immortalized lymphocytes from Alzheimer's dementia patients.},
  author={Ursula Mu{\~n}oz and Fernando Bartolome and F{\'e}lix Bermejo and {\'A}ngeles Mart{\'i}n-Requero},
  journal={Neurobiology of aging},
  year={2008},
  volume={29 10},
  pages={1474-84}
}
Cyclin-dependent kinase inhibitor p27(kip1) (p27), a critical determinant for cell cycle progression, is an important regulation target of mitogenic signals. We have recently reported the existence of a molecular link between decreased p27 levels and enhanced phosphorylation of pRb protein and proliferation of immortalized lymphocytes from Alzheimer's disease (AD) patients. These cell cycle disturbances might be considered systemic manifestations, which mirror changes thought to occur in the… CONTINUE READING