Enhanced proliferation and dopaminergic differentiation of ventral mesencephalic precursor cells by synergistic effect of FGF2 and reduced oxygen tension.

@article{Jensen2011EnhancedPA,
  title={Enhanced proliferation and dopaminergic differentiation of ventral mesencephalic precursor cells by synergistic effect of FGF2 and reduced oxygen tension.},
  author={Pia S{\o}ndergaard Jensen and Jan-Bert Gramsbergen and Jens Zimmer and Hans Rudolf Widmer and Morten Meyer},
  journal={Experimental cell research},
  year={2011},
  volume={317 12},
  pages={
          1649-62
        }
}
Effective numerical expansion of dopaminergic precursors might overcome the limited availability of transplantable cells in replacement strategies for Parkinson's disease. Here we investigated the effect of fibroblast growth factor-2 (FGF2) and FGF8 on expansion and dopaminergic differentiation of rat embryonic ventral mesencephalic neuroblasts cultured at high (20%) and low (3%) oxygen tension. More cells incorporated bromodeoxyuridine in cultures expanded at low as compared to high oxygen… CONTINUE READING
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