Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells

@inproceedings{Han2014EnhancedPA,
  title={Enhanced proliferation and differentiation of Oct4- and Sox2-overexpressing human adipose tissue mesenchymal stem cells},
  author={Sei-Myoung Han and Sang-Hun Han and Ye-Rin Coh and Goo Jang and Jeong Chan Ra and Sung-Keun Kang and Hee-woo Lee and Hwa-Young Youn},
  booktitle={Experimental & Molecular Medicine},
  year={2014}
}
Mesenchymal stem cells (MSCs) are attractive candidates for clinical repair or regeneration of damaged tissues. Oct4 and Sox2, which are essential transcription factors for pluripotency and self-renewal, are naturally expressed in MSCs at low levels in early passages, and their levels gradually decrease as the passage number increases. Therefore, to improve MSC proliferation and stemness, we introduced human Oct4 and Sox2 for conferring higher expansion and differentiation capabilities. The… CONTINUE READING
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