Enhanced production of unusual triterpenoids from Kadsura angustifolia fermented by a symbiont endophytic fungus, Penicillium sp. SWUKD4.1850.

  title={Enhanced production of unusual triterpenoids from Kadsura angustifolia fermented by a symbiont endophytic fungus, Penicillium sp. SWUKD4.1850.},
  author={Dan Qin and Weiyun Shen and Junqi Wang and Meijun Han and Fangni Chai and Xiaoxiang Duan and Xiao Yan and Jiali Guo and Tiancong Gao and Shihao Zuo and Jinyan Dong},

Resorcylic Acid Lactones Produced by an Endophytic Penicillium ochrochloron Strain from Kadsura angustifolia

Four new β-resorcylic acid lactones, including penochrochlactone A (2), 4-O-desmethyl-aigialomycin B (4), and penochromine C and D (5 and 6) were isolated from a mycelial solid culture of the endophytic fungus Penicillium ochrochloron SWUKD4.1850 from the medicinal plant Kadsura angustifolia by sequential purification

Microbial assemblages of Schisandraceae plants and the correlations between endophytic species and the accumulation of secondary metabolites

Schisandraceae are medicinal plants with significant medicinal and economic value. However, little is known about the microbiota assembly of Schisandraceae plants and the relationship between

Biological Activity of Endophytic Fungi from the Roots of the Medicinal Plant Vernonia anthelmintica

Endophytic fungi were first isolated from the fresh root of the Chinese medicinal plant Vernonia anthelmintica collected from the Hotan Prefecture within the Xinjiang Autonomous region of the People’s Republic of China to identify in vitro biological activity assays including antimicrobial, antioxidant, cytotoxic, antidiabetic and tyrosinase activity.

Endophytic Penicillium species and their agricultural, biotechnological, and pharmaceutical applications

This review comprehensively summarized in this review available data (2000–2019) regarding bioactive compounds isolated from endophytic Penicillium species as well as the application of these fungi in multiple agricultural and biotechnological processes.

Progress on Terpenoids With Biological Activities Produced by Plant Endophytic Fungi in China Between 2017 and 2019

200 terpenoids with biological activities that are derived from plant endophytic fungi in China between 2017 and 2019 displayed multifarious biological activities, including antimicrobial, antipathogenic, and anti-inflammatory activities, as well as cytotoxicity, antitumor agents, and enzyme inhibition.

Biotransformation ability of endophytic fungi: from species evolution to industrial applications

This work mainly summarized recent research progress in this field, providing a reference for further research and application of fungal endophytes for the production/innovation of bioactive molecules, food and nutrition, agriculture, and environment.

Endophytic Fungal Terpenoids: Natural Role and Bioactivities

The role of endophytic fungi in plant health, fungal terpenoids in multiple interactions, and bioactive fungal Terpenoids recently reported from endophytes are described, mainly from plants used in traditional medicine, as well as from algae and mangroves.

Endophytic Fungi: An Effective Alternative Source of Plant-Derived Bioactive Compounds for Pharmacological Studies

It was revealed that endophytic fungi had high potential to be harnessed as an alternative source of secondary metabolites for pharmacological studies, and special attention paid to the exploration of pharmacological activities and mechanisms of action of certain compounds.



Eleven new highly oxygenated triterpenoids from the leaves and stems of Schisandra chinensis.

The activities of compounds 1, 2, 7, and 12–14 against HSV-2 and adenovirus were evaluated for the first time, and of these compounds, 13 was the most active inhibitor of HSV -2, with a selectivity index value as high as 29.95.

Degradation of the polyamine alkaloid aphelandrine by endophytic fungi isolated from Aphelandra tetragona.

The ability of the endophytes to metabolize aphelandrine suggests an ecological adaptation of the symbionts to their host and the possibility of using the ap helandrine metabolism as a taxonomic character is briefly discussed.

Compounds from Kadsura angustifolia with anti-HIV activity.

Endohyphal Bacterium Enhances Production of Indole-3-Acetic Acid by a Foliar Fungal Endophyte

Together these results speak to a facultative symbiosis between an endophyte and endohyphal bacterium that strongly influences IAA production, providing a new framework in which to explore endophytes-plant interactions.

Influence of fungal endophyte infection on phenolic content and antioxidant activity in grasses: interaction between Lolium perenne and different strains of Neotyphodium lolii.

In conclusion, changes in phenolic composition were merely quantitative, and Infection with N. lolii significantly influenced L. perenne phenolic content and antioxidant activity.

Three New Lanostane Triterpenoids, Inonotsutriols A, B, and C, from Inonotus obliquus

Three new lanostane-type triterpenoids, inonotsutriols A (1), B (2), and C (3) were isolated from the sclerotia of Inonotus obliquus (Pers.: Fr.) (Japanese name: kabanoanatake; Russian name: chaga).

Four New Nortriterpenoids from Schisandra lancifolia

Four new highly oxygenated nortriterpenoids, lancifodilactones O-R (1-4), together with six known ones, i.e., 5-10, were isolated from the leaves and stems of Schisandra lancifolia. Their structures

Hydroxylation of the Triterpenoid Nigranoic Acid by the Fungus Gliocladium roseum YMF1.00133

This is the first report of the biotransformation of the A‐ring‐secocycloartene triterpenoid, nigranoic acid.