Enhanced production of lovastatin by Omphalotus olearius (DC.) Singer in solid state fermentation.

@article{Atl2015EnhancedPO,
  title={Enhanced production of lovastatin by Omphalotus olearius (DC.) Singer in solid state fermentation.},
  author={Burcu Atlı and M. Yamaç and Zeki Yıldız and Omoanghe S Isikhuemnen},
  journal={Revista iberoamericana de micologia},
  year={2015},
  volume={32 4},
  pages={
          247-51
        }
}
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This is the first report on the production of lovastatin using a mixed substrate solid state fermentation using Monascus purpureus and to optimize the combination of the solid substrates by response surface methodology.
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In comparison with glycerol and glucose, the rice powder becomes a more suitable carbon source and represents a great potential for the production of Lvs.
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The lovastatin amount produced by commercial strains, Aspergillus terreus NRRL 255 and Penicillium citrinum NRRL 1841, was nearly comparable to the amountproduced by Pleurotus ostreatus OBCC 1031 and Omphalotus olearius O BCC 2002.
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The production of lovastatin and its HMG-CoA reductase activity produced by fruit bodies and mycelial liquid cultures of domestic edible mushrooms (8 fungal strains) was determined and deter-mining TLC analysis showed same Rf value, which was identical to that of the standard Lovastatin.
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Insight is provided into the different lovastatin production strategies employed by SSF, its advantages over SmF, optimisation parameters, Lovastatin genetics etc.
Optimization of Fermentation Parameters for Higher Lovastatin Production in Red Mold Rice through Co-culture of Monascus purpureus and Monascus ruber
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Lovastatin biosynthetic genes of Aspergillus terreus are expressed differentially in solid-state and in liquid submerged fermentation
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The results show that the higher lovastatin production in SSF is related to a more intense transcription of these biosynthetic genes, and that osmotic stress alone is not responsible for the higher gene expression inSSF.
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Biomolecule Profiles in Inedible Wild Mushrooms with Antioxidant Value
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Fomitopsis pinicola revealed a very high phenolics concentration and powerful antioxidant properties, mainly reducing power (EC50 value 60 μg/mL similar to the standard Trolox®), which could find applications in the prevention of free radical-related diseases as a source of bioactive compounds.
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