Enhanced production of coenzyme Q10 by self-regulating the engineered MEP pathway in Rhodobacter sphaeroides.

@article{Lu2014EnhancedPO,
  title={Enhanced production of coenzyme Q10 by self-regulating the engineered MEP pathway in Rhodobacter sphaeroides.},
  author={Wenqiang Lu and Lidan Ye and Haoming Xu and Wenping Xie and Jiali Gu and Hongwei Yu},
  journal={Biotechnology and bioengineering},
  year={2014},
  volume={111 4},
  pages={761-9}
}
Fine-tuning the expression level of an engineered pathway is crucial for the metabolic engineering of a host toward a desired phenotype. However, most engineered hosts suffer from nonfunctional protein expression, metabolic imbalance, cellular burden or toxicity from intermediates when an engineered pathway is first introduced, which can decrease production of the desired product. To circumvent these obstacles, we developed a self-regulation system utilizing the trc/tac promoter, LacI(q… CONTINUE READING

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