Enhanced production of Fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process.

@article{Zhu2014EnhancedPO,
  title={Enhanced production of Fumigaclavine C in liquid culture of Aspergillus fumigatus under a two-stage process.},
  author={Yi-Xiang Zhu and Ling-Yun Yao and Ruihua Jiao and Yan-hua Lu and Ren Xiang Tan},
  journal={Bioresource technology},
  year={2014},
  volume={152},
  pages={162-8}
}
Fumigaclavine C (FC) produced by Aspergillus fumigatus is a conidiation associated ergot alkaloid with strong anti-inflammatory activity. However, its wide application has been severely limited by low FC production from submerged culture. In this work, a novel two-stage culture process by combining shake culture with static culture was proposed to enhance the production of FC. After the process optimization, the FC production reached 62.7 mg/L, which was significantly higher than ever report… CONTINUE READING

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