Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.

@article{Shafaati2011EnhancedPO,
  title={Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo.},
  author={Marjan Shafaati and Maria Olin and Ann B{\aa}vner and Hanna Pettersson and Bj{\"o}rn Rozell and Steve Meaney and Paolo Parini and Ingemar Bj{\"o}rkhem},
  journal={Journal of internal medicine},
  year={2011},
  volume={270 4},
  pages={377-87}
}
BACKGROUND Oxysterols such as 24S-hydroxycholesterol (OHC) and 27-OHC are intermediates of cholesterol excretion pathways. In addition, they are putative endogenous agonists of the liver X receptor (LXR) class of nuclear hormone receptors and are thought to be important mediators of cholesterol-dependent gene regulation. 24S-OHC is one of the most efficient endogenous LXR agonists known and is present in the brain and in the circulation at relatively high levels. OBJECTIVES To explore the… CONTINUE READING
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