Enhanced process monitoring of fed-batch penicillin cultivation using time-varying and multivariate statistical analysis.

@article{Lee2004EnhancedPM,
  title={Enhanced process monitoring of fed-batch penicillin cultivation using time-varying and multivariate statistical analysis.},
  author={Jong Min Lee and Chang Yoo and In-Beum Lee},
  journal={Journal of biotechnology},
  year={2004},
  volume={110 2},
  pages={119-36}
}
On-line monitoring of penicillin cultivation processes is crucial to the safe production of high-quality products. In the past, multiway principal component analysis (MPCA), a multivariate projection method, has been widely used to monitor batch and fed-batch processes. However, when MPCA is used for on-line batch monitoring, the future behavior of each new batch must be inferred up to the end of the batch operation at each time and the batch lengths must be equalized. This represents a major… CONTINUE READING
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