Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.

@article{Pirinen2007EnhancedPC,
  title={Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism.},
  author={Eija Pirinen and Teemu Kuulasmaa and Marko Pietil{\"a} and Sami Heikkinen and Maija Tusa and Paula Itkonen and Susanna Boman and Joanna Skommer and Antti Virkam{\"a}ki and Esa Hohtola and Mikko I Kettunen and Szabolcs Fatrai and Emilia Kansanen and Suvi Koota and Kirsi Niiranen and Jyrki J. Parkkinen and A L Levonen and Seppo Yl{\"a}-Herttuala and J Kalervo Hiltunen and Leena Alhonen and Ulf Smith and Juhani E J{\"a}nne and Markku Laakso},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 13},
  pages={4953-67}
}
Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) is an attractive candidate gene for type 2 diabetes, as genes of the oxidative phosphorylation (OXPHOS) pathway are coordinatively downregulated by reduced expression of PGC-1 alpha in skeletal muscle and adipose tissue of patients with type 2 diabetes. Here we demonstrate that transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) had… CONTINUE READING
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