Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain.

  title={Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain.},
  author={T Tokime and Kazuhiko Nozaki and Toshiyuki Sugino and H. Ishikura K. Kikuchi and N. Hashimoto and Kunihiro Ueda},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={18 9},
Nitric oxide from neuronal cells plays detrimental roles in glutamate neurotoxicity and in focal brain ischemia. Nitric oxide directly damages DNA, and breaks in the DNA strands activate poly(ADP-ribose) polymerase (PARP), which brings poly(ADP-ribosyl)ation of the nuclear proteins. The excessive activation of PARP is thought to cause depletion of ATP and the energy failure resulting in cell death. To clarify the involvement of poly(ADP-ribosyl)ation in ischemic insult, we examined poly(ADP… CONTINUE READING