Enhanced pilocarpine-induced oral activity responses in neonatal 6-OHDA treated rats.

@article{Kostrzewa1993EnhancedPO,
  title={Enhanced pilocarpine-induced oral activity responses in neonatal 6-OHDA treated rats.},
  author={Richard M. Kostrzewa and Dermot Neely},
  journal={Pharmacology, biochemistry, and behavior},
  year={1993},
  volume={45 3},
  pages={737-40}
}
Neonatal destruction of rat nigrostriatal dopaminergic fibers results in an enhanced oral activity response to both dopamine (DA) D1 and serotonin (5-HT) agonists. Because cholinergic systems represent another one of the neural circuits involved in oral behavior, it was of interest to determine whether muscarinic receptors might also be sensitized in the lesioned rats. At 3 days after birth, rats were pretreated with desipramine HCl (20 mg/kg, IP) 1 h before 6-hydroxydopamine (6-OHDA) HBr (100… CONTINUE READING