Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide.

@article{Jiang1999EnhancedPR,
  title={Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide.},
  author={Jun-lin Jiang and Peter Thor{\'e}n and Giuseppina Caligiuri and G{\"o}ran K. Hansson and John Pernow},
  journal={British journal of pharmacology},
  year={1999},
  volume={128 3},
  pages={
          637-46
        }
}
1. Mice lacking the apolipoprotein E and low density lipoprotein receptor genes (E degrees xLDLR degrees ) develop atherosclerosis. The aim of this study was to investigate changes in endothelium-dependent vasodilation and vasomotion in thoracic aortic rings of E degrees xLDLR degrees mice. 2. K+-induced contractions of the aorta from E degrees xLDLR degrees mice were stronger than those from control mice. The sensitivity of E degrees xLDLR degrees aorta to phenylephrine (PE) was decreased but… CONTINUE READING
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