Enhanced phagemid particle gene transfer in camptothecin-treated carcinoma cells.

@article{Burg2002EnhancedPP,
  title={Enhanced phagemid particle gene transfer in camptothecin-treated carcinoma cells.},
  author={Michael A. Burg and Kristen Jensen-Pergakes and Ana Maria Gonzalez and Prenn Ravey and Andrew Baird and David Larocca},
  journal={Cancer research},
  year={2002},
  volume={62 4},
  pages={977-81}
}
Engineered phage-based vectors are an attractive alternative strategy for gene delivery because they possess no natural mammalian cell tropism and can be genetically modified for specific applications. Genotoxic treatments that increase the transduction efficiency of single-stranded adeno-associated virus were tested on cells transfected by single-stranded phage. Indeed, green fluorescent protein transgene expression by epidermal growth factor-targeted phagemid particles increased with heat… CONTINUE READING

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