Enhanced permeation of methotrexate in vitro by ion pair formation with L-arginine.

  title={Enhanced permeation of methotrexate in vitro by ion pair formation with L-arginine.},
  author={V. D. Ivaturi and S. Kim},
  journal={Journal of pharmaceutical sciences},
  volume={98 10},
  • V. D. Ivaturi, S. Kim
  • Published 2009
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • Ion paired solutions of methotrexate in L-arginine/water/propylene glycol systems were evaluated for their potential to enhance the permeation of methotrexate across rabbit nasal mucosa in vitro. The partition coefficient of methotrexate in the methotrexate: L-arginine ion paired systems was observed to be 24 times greater than that of the methotrexate system without L-arginine. The ion pair formation between methotrexate and L-arginine was confirmed by a decrease in the conductivity of the… CONTINUE READING
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