Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice.

@article{Zhang2008EnhancedPA,
  title={Enhanced peripheral analgesia using virally mediated gene transfer of the mu-opioid receptor in mice.},
  author={Guohua Zhang and Husam Aldeen Mohammad and Brad D Peper and Srinivasa N Raja and Steven P Wilson and Sarah M. Sweitzer},
  journal={Anesthesiology},
  year={2008},
  volume={108 2},
  pages={305-13}
}
BACKGROUND The use of opioids to treat pain is often limited by side effects mediated through the central nervous system. The current study used a recombinant herpes simplex virus type 1 to increase expression of the mu-opioid receptor (muOR) in primary afferent neurons. The goal of this strategy was to enhance peripheral opioid analgesia. METHODS Cutaneous inoculation with herpes simplex virus containing muOR complementary DNA (cDNA) in antisense (SGAMOR) or sense (SGMOR) orientation… CONTINUE READING

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Herpes vector-mediated gene transfer in the treatment of chronic pain.

Molecular therapy : the journal of the American Society of Gene Therapy • 2009

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