Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.

@article{ChoisyRossi2004EnhancedPO,
  title={Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.},
  author={Caroline-Morgane Choisy-Rossi and Thomas M. Holl and Melissa Pierce and Harold D. Chapman and David V Serreze},
  journal={Journal of immunology},
  year={2004},
  volume={173 6},
  pages={3791-800}
}
For unknown reasons, the common MHC class I variants encoded by the H2g7 haplotype (Kd, Db) aberrantly elicit autoreactive CD8 T cell responses essential to type 1 diabetes development when expressed in NOD mice, but not other strains. In this study, we show that interactive non-MHC genes allow a NOD-derived diabetogenic CD8 T cell clonotype (AI4) to be negatively selected at far greater efficiency in C57BL/6 mice congenically expressing H2g7 (B6.H2g7). However, the few AI4 T cells escaping… CONTINUE READING

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