Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.

@article{Nijenhuis2005EnhancedPC,
  title={Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia.},
  author={Tom Nijenhuis and Volker Vallon and Annemiete W C M van der Kemp and Johannes Loffing and Joost G. J. Hoenderop and Ren{\'e} J M Bindels},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 6},
  pages={1651-8}
}
Thiazide diuretics enhance renal Na+ excretion by blocking the Na+-Cl- cotransporter (NCC), and mutations in NCC result in Gitelman syndrome. The mechanisms underlying the accompanying hypocalciuria and hypomagnesemia remain debated. Here, we show that enhanced passive Ca2+ transport in the proximal tubule rather than active Ca2+ transport in distal convolution explains thiazide-induced hypocalciuria. First, micropuncture experiments in mice demonstrated increased reabsorption of Na+ and Ca2… CONTINUE READING