Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene

  title={Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene},
  author={Miranda M. Lim and Zuoxin Wang and Daniel E Olaz{\'a}bal and Xianghui Ren and Ernest F. Terwilliger and Larry J. Young},
The molecular mechanisms underlying the evolution of complex behaviour are poorly understood. The mammalian genus Microtus provides an excellent model for investigating the evolution of social behaviour. Prairie voles (Microtus ochrogaster) exhibit a monogamous social structure in nature, whereas closely related meadow voles (Microtus pennsylvanicus) are solitary and polygamous. In male prairie voles, both vasopressin and dopamine act in the ventral forebrain to regulate selective affiliation… 
Monogamy evolves through multiple mechanisms: evidence from V1aR in deer mice.
There are no consistent differences in V1aR expression pattern between monogamous and promiscuous species in regions of the brain known to influence mating behavior, suggesting that mating-system variation in rodents is mediated by multiple genetic mechanisms.
Mammalian monogamy is not controlled by a single gene.
The evolutionary approach reveals that monogamy in rodents is not controlled by a single polymorphism in the promoter region of the avpr1a gene, resolving the contradiction between the claims for an evolutionarily conserved genetic programming of social behavior in mammals and the vast evidence for highly complex and flexible mating systems.
Individual Differences in Social Behavior and Cortical Vasopressin Receptor: Genetics, Epigenetics, and Evolution
Recent work on individual differences in the expression of the vasopressin 1a receptor (V1aR), a major regulator of social behavior, in the neocortex of the socially monogamous prairie vole, provides insight into how genetic, epigenetic and evolutionary forces interact to shape the social brain.
Polymorphism at the avpr1a locus in male prairie voles correlated with genetic but not social monogamy in field populations
The relationship between avpr1a length polymorphism and monogamy among male prairie voles living in 0.1 ha enclosures during a time similar to their natural lifespan is examined, showing that melding ecological field studies with neurogenetics can substantially augment the understanding of the effects of genes and environment on social behaviours.
Distributions of oxytocin and vasopressin 1a receptors in the Taiwan vole and their role in social monogamy.
The neuroanatomical distribution of OTR and V1aR binding sites in naturally occurring populations of Taiwan voles, which purportedly display social monogamy, is characterized to lay a foundation for future investigations into the role of these neuropeptides in Taiwan vole social behavior.


A role for central vasopressin in pair bonding in monogamous prairie voles
It is demonstrated that central AVP is both necessary and sufficient for selective aggression and partner preference formation, two critical features of pair bonding in the monogamous prairie vole.
Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole
A role for ventral pallidal V1aR in affiliation and social attachment is demonstrated and a potential molecular mechanism for species differences in social organization is provided.
Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole
It is shown that centrally administered arginine vasopressin increases affiliative behaviour in the highly social, monogamous prairie vole, but not in the relatively asocial, promiscuous montane vole.
Species Differences in Paternal Behavior and Aggression in Peromyscus and Their Associations with Vasopressin Immunoreactivity and Receptors
This study proposes the hypothesis that aggression may be better correlated with species patterns of AVP-ir staining density and receptor distribution, and suggests that Parental behavior does not appear to predict differences in patterns of Analsis vasopressinergic neurons and receptors across species.
Functional microsatellite polymorphism associated with divergent social structure in vole species.
The functional role of a microsatellite segment in the 5' region of V1aR that differs significantly between monogamous and nonmonogamous vole species with divergent V 1aR expression patterns is examined to suggest that significant evolutionary changes in social behavior can occur through variation in regulatory regions of genes already involved in social Behavior.
Extraordinary diversity in vasopressin (V1a) receptor distributions among wild prairie voles (Microtus ochrogaster): Patterns of variation and covariation
The data indicate that the prairie vole would be a useful model for exploring how individual differences in gene expression influence complex social behaviors, and suggests that shared mechanisms of transcriptional regulation may limit the patterns of gene expression.
Patterns of brain vasopressin receptor distribution associated with social organization in microtine rodents
Different patterns of brain vasopressin receptor binding in the monogamous prairie vole and the congeneric nonmonogamous (promiscuous) montane vole suggest the importance of this neuropeptide for the mediation of behaviors related to social organization.
Species differences in V1a receptor gene expression in monogamous and nonmonogamous voles: behavioral consequences.
Using in situ hybridization in 2 species of voles with strikingly different patterns of V1a binding sites and social behaviors, it is demonstrated that differences in V 1a receptor binding sites are due to species differences in regional V1A receptor gene expression.
Cooperative breeding and monogamy in prairie voles: influence of the sire and geographical variation
Some traits associated with the social system may show intraspecific variation and can be influenced by the presence or absence of the sire during rearing, as well as suggestive of monogamy.
Monogamy in Mammals
  • D. Kleiman
  • Biology
    The Quarterly Review of Biology
  • 1977
This review considers the behavioral, ecological, and reproductive characteristics of mammals exhibiting monogamy, i.e., mating exclusivity. From a discussion of the life histories of selected