Enhanced parasympathetic activity in Chagas disease still stands in need of proof.

@article{Ribeiro2009EnhancedPA,
  title={Enhanced parasympathetic activity in Chagas disease still stands in need of proof.},
  author={Ant{\^o}nio Luiz Pinho Ribeiro and Antonio Carlos Campos Campos de Carvalho and F. Lombardi and Mauro M Teixeira and Manoel {\'O}tavio da Costa Rocha},
  journal={International journal of cardiology},
  year={2009},
  volume={135 3},
  pages={406-8}
}
Cardiac vagal modulation impairment is a typical feature of Chagas disease (ChD) and is correlated to antagonistic anti-M2 autoantibodies activity. In this letter, we analyze the hypothesis that, in ChD, anti-muscarinic antibody activity could simultaneously increase parasympathetic tonus (decreasing heart rate) and decrease vagal modulation over cardiac sinus node (reducing heart rate variability - HRV). Although attractive, this hypothesis is not supported by empirical data, since reduction… CONTINUE READING