Enhanced pan-peroxisome proliferator-activated receptor gene and protein expression in adipose tissue of diet-induced obese mice treated with telmisartan.

@article{PennadeCarvalho2014EnhancedPP,
  title={Enhanced pan-peroxisome proliferator-activated receptor gene and protein expression in adipose tissue of diet-induced obese mice treated with telmisartan.},
  author={Aline Penna-de-Carvalho and Francielle Graus-Nunes and J{\'u}lia Rabelo-Andrade and Carlos Alberto Mandarim-de-Lacerda and Vanessa Souza-Mello},
  journal={Experimental physiology},
  year={2014},
  volume={99 12},
  pages={1663-78}
}
Telmisartan has previously been used to target obesity, showing peroxisome proliferator-activated receptor (PPAR) β/δ-related effects in white adipose tissue (WAT). We sought to evaluate whether telmisartan enhances gene and protein expression of all PPAR isoforms in WAT and brown adipose tissue (BAT), as well as their downstream effects upon insulin resistance, adipokine profile and adaptive thermogenesis. Male C57BL/6 mice were fed standard chow (SC; 10% lipids) or high-fat diet (HF; 50… CONTINUE READING

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