Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.

@article{Bayir2005EnhancedOS,
  title={Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.},
  author={H{\"u}lya A Bayir and Valerian E Kagan and Grigory G. Borisenko and Yulia Y. Tyurina and Keri L. Janesko and Vincent A Vagni and Timothy R Billiar and Deborah Lou Williams and Patrick M Kochanek},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2005},
  volume={25 6},
  pages={673-84}
}
Studies in experimental traumatic brain injury (TBI) suggest both deleterious and protective effects of inducible nitric oxide synthase (iNOS). Early after injury, iNOS may be detrimental via formation of peroxynitrite and iNOS inhibitors are protective. In contrast, we reported impaired long-term functional outcome after TBI in iNOS knockout (ko) versus wild-type (wt) mice. To elucidate potential neuroprotective and neurotoxic mechanisms for iNOS, we studied nitric oxide formation by electron… CONTINUE READING