Enhanced osteopontin expression and macrophage infiltration in MRL-Fas(lpr) mice with lupus nephritis.

@article{Wthrich1998EnhancedOE,
  title={Enhanced osteopontin expression and macrophage infiltration in MRL-Fas(lpr) mice with lupus nephritis.},
  author={Rudolf Peter W{\"u}thrich and Xiujun Fan and T Ritthaler and Vladimir Sibalic and De Jiang Yu and Johannes Loffing and Brigitte Kaissling},
  journal={Autoimmunity},
  year={1998},
  volume={28 3},
  pages={139-50}
}
MRL-Fas(lpr) mice spontaneously develop a chronic lupus-like renal disease, characterized by immune complex-mediated glomerulonephritis and abundant mononuclear cell infiltration in the interstitium. In the present study we have examined whether the macrophage chemoattractant osteopontin (Opn) could be important in the recruitment of macrophages in this murine model of autoimmune renal injury. We have examined the expression of Opn in the kidney of MRL-Fas(lpr) mice and have correlated Opn… CONTINUE READING

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