Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells.

@article{Dalbeth2008EnhancedOI,
  title={Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells.},
  author={Nicola D Dalbeth and Timothy L Smith and Bridget Nicolson and Barnaby Clark and Karen E. Callon and Dorit Naot and Dorian O. Haskard and Fiona Marion Florence McQueen and Ian R Reid and Jillian Cornish},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 6},
  pages={1854-65}
}
OBJECTIVE To analyze cellular mechanisms of bone erosion in gout. METHODS Peripheral blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) from patients with gout were analyzed for the presence of osteoclast precursors. Fixed tophus and bone samples were analyzed by immunohistochemistry. Mechanisms of osteoclastogenesis were studied by culturing murine preosteoclast RAW 264.7 cells, bone marrow stromal ST2 cells, and human synovial fibroblasts with monosodium urate… CONTINUE READING
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