Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF.

@article{Joensuu2015EnhancedOD,
  title={Enhanced osteoblastic differentiation and bone formation in co-culture of human bone marrow mesenchymal stromal cells and peripheral blood mononuclear cells with exogenous VEGF.},
  author={Katriina Joensuu and Leena Uusitalo and Jessica J. Alm and Hannu T. Aro and Teuvo A. Hentunen and Terhi J. Heino},
  journal={Orthopaedics & traumatology, surgery & research : OTSR},
  year={2015},
  volume={101 3},
  pages={381-6}
}
BACKGROUND Despite recent advances in bone tissue engineering, efficient bone formation and vascularization remains a challenge for clinical applications. HYPOTHESIS The aim of this study was to investigate if the osteoblastic differentiation of human mesenchymal stromal cells (MSCs) can be enhanced by co-culturing them with peripheral blood (PB) mononuclear cells (MNCs), with and without vascular endothelial growth factor (VEGF), a coupling factor of bone formation and angiogenesis… CONTINUE READING