Enhanced osseous integration of human trabecular allografts following surface modification with bioactive lipids

@article{Wang2015EnhancedOI,
  title={Enhanced osseous integration of human trabecular allografts following surface modification with bioactive lipids},
  author={Tiffany Wang and Jack R Krieger and Cynthia Y.-H. Huang and Anusuya Das and Michael P Francis and Roy C Ogle and Edward A. Botchwey},
  journal={Drug Delivery and Translational Research},
  year={2015},
  volume={6},
  pages={96-104}
}
In this study, we used extracellular matrix (ECM) gels and human bone allograft as matrix vehicles to deliver the sphingolipid growth factor FTY720 to rodent models of tibial fracture and a critical-sized cranial defect. We show that FTY720 released from injectable ECM gels may accelerate callous formation and resolution and bone volume in a mouse tibial fracture model. We then show that FTY720 binds directly to human trabecular allograft bone and releases over 1 week in vitro. Rat critical… CONTINUE READING
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